For decades, researchers believed that if people with diabetes lowered their blood sugar to normal levels, they would no longer be at high risk of dying from heart disease. But a major federal study of more than 10,000 middle-aged and older people with Type 2 diabetes has found that lowering blood sugar actually increased their risk of death, researchers reported yesterday. The researchers announced that they were abruptly halting that part of the study, whose surprising results call into question how the disease, which affects 21 million Americans, should be managed. Among the study participants who were randomly assigned to get their blood sugar levels to nearly normal, there were 54 more deaths than in the group whose levels were less rigidly controlled. The patients were in the study for an average of four years when investigators called a halt to the intensive blood sugar lowering and put all of them on the less intense regimen. The results do not mean blood sugar is meaningless. Lowered blood sugar can protect against kidney disease, blindness and amputations, but the findings inject an element of uncertainty into what has been dogma — that the lower the blood sugar the better and that lowering blood sugar levels to normal saves lives. Medical experts were stunned. “It’s confusing and disturbing that this happened,” said Dr. James Dove, president of the American College of Cardiology. “For 50 years, we’ve talked about getting blood sugar very low. Everything in the literature would suggest this is the right thing to do,” he added.
Dr. Irl Hirsch, a diabetes researcher at the University of Washington, said the study’s results would be hard to explain to some patients who have spent years and made an enormous effort, through diet and medication, getting and keeping their blood sugar down. They will not want to relax their vigilance, he said.
“It will be similar to what many women felt when they heard the news about estrogen,” Dr. Hirsch said. “Telling these patients to get their blood sugar up will be very difficult.”
This is continuing evidence that medical science is not an exact science, if it can be considered a science at all.
February 5, 2008 LIMITED EVIDENCE ON BEST TREATMENTS FOR PROSTATE CANCER
The benefits and risks of various treatments for localized prostate cancer are difficult to assess due to the lack of high-quality evidence, according to an Annals of Internal Medicine article published early online. The systematic review, undertaken for the federal Agency for Healthcare Research and Quality, evaluated the literature through November 2007. Among its conclusions:
- The evidence is especially scant with regard to men whose disease was detected by PSA.
- The lack of data from high-quality trials "remains the main barrier to well-informed decision making."
- Despite their widespread use, such treatments as intensity-modulated radiation therapy, androgen deprivation, and cryotherapy have not been assessed in randomized trials.
February 4, 2008 SUGARY SOFT DRINKS, FRUCTOSE, INCREASE RISK OF GOUT IN MEN
High consumption of sugar-sweetened soft drinks and fructose may increase the risk for gout in men, BMJ reports. More than 46,000 male health professionals aged 40 to 75 completed food-frequency questionnaires at baseline and every 4 years thereafter. During 12 years' follow-up, 1.6% developed gout. After multivariable adjustment, gout risk rose significantly with increasing consumption of sugar-sweetened soft drinks. Compared with men who consumed less than one sugary soft drink a month, those consuming five to six drinks a week had a 29% increased risk; one a day, a 45% increase; and two or more daily, an 85% increase. Risk also rose with increasing consumption of other high-fructose products, such as fruit juice, apples, and oranges.
January 29, 2008 CAFFEINE MAY AFFECT CONTROL OF GLUCOSE IN TYPE 2 DIABETES
A study reported in Diabetes Care found that consuming 500 mg of caffeine daily (about 4 cups of coffee) daily might impair glucose controls in type 2 diabetics. The study included 10 coffee drinkers whose diabetes was controlled with diet, exericse and oral medications. On day 1 participants took 250mg of caffeine or placebo pills at both breakfast and lunch and on day 2, took the opposite. They consumed no other caffeine during the study. The average daytime glucose level was significantly higher in the caffeine group than the placebo group. The authors reported their concern that caffeine makes diabetes more difficult to treat and results in more complications.
January 12, 2008 TREATING A DISEASE THAT MAY NOT EXIST?
Pfizer says it's real. Then again, they have an incentive to believe fibromyalgia exits. Some doctors agree and others disagree. The one thing we can't dispute is the pain. But patient advocacy groups and doctors who specialize in fibromyalgia, the Lyrica approval is a milestone. They say they hope Lyrica and two other drugs that may be approved this year will legitimize fibromyalgia, just as Prozac brought depression into the mainstream. other doctors — including the one who wrote the 1990 paper that defined fibromyalgia but who has since changed his mind — say that the disease does not exist and that Lyrica and the other drugs will be taken by millions of people who do not need them. As diagnosed, fibromyalgia primarily affects middle-aged women and is characterized by chronic, widespread pain of unknown origin. Many of its sufferers are afflicted by other similarly nebulous conditions, like irritable bowel syndrome. Because fibromyalgia patients typically do not respond to conventional painkillers like aspirin, drug makers are focusing on medicines like Lyrica that affect the brain and the perception of pain. Advocacy groups and doctors who treat fibromyalgia estimate that 2 to 4 percent of adult Americans, as many as 10 million people, suffer from the disorder. Those figures are sharply disputed by those doctors who do not consider fibromyalgia a medically recognizable illness and who say that diagnosing the condition actually worsens suffering by causing patients to obsess over aches that other people simply tolerate. Further, they warn that Lyrica’s side effects, which include severe weight gain, dizziness and edema, are very real, even if fibromyalgia is not. Despite the controversy, the American College of Rheumatology, the Food and Drug Administration and insurers recognize fibromyalgia as a diagnosable disease. And drug companies are aggressively pursuing fibromyalgia treatments, seeing the potential for a major new market.
The diagnosis of fibromyalgia itself worsens the condition by encouraging people to think of themselves as sick and catalog their pain, said Dr. Nortin Hadler, a rheumatologist and professor of medicine at the University of North Carolina who has written extensively about fibromyalgia.
“These people live under a cloud,” he said. “And the more they seem to be around the medical establishment, the sicker they get.”
January 10, 2008 DR. DRUG REP
Interesting article found in the NY Times on November 25, 2007 is actually a good addendum to the article about psychiatrists from January 9. This was written by a psychiatrist: "On a blustery fall New England day in 2001, a friendly representative from Wyeth Pharmaceuticals came into my office in Newburyport, MA, and made me an offer I found hard to refuse. He asked me if I would like to give talks to other doctors about using Effexor XR for treating depression. He told me that I would go around to doctors' offices during lunchtime and talk about some of the features of Effexor. Wyeth would provide slides and even pay me to train. I would be paid $500 for a one hour lunch and learn talks at doctors' offices or $750 if I had to travel an hour." He saw some studies showing that Effexor was slightly more effective than the prozacs, paxils and zolofts of the world. He relates a story where one doctor at the learning session had given talks about Neurontin being effective for bipolar disorder. He doctor was skeptical because he had tried prescribing it for his bipolar patients and did not find it effective. He wondered if this doctor's positive opinion was influenced by the money he was paid for the talks. The long article goes on to say that he started giving the talks and felt uncomfortable because he felt like a drug rep rather than the doctor that he was. Plus as more data came out comparing effexor to other drugs, the remisson advantage was only 5% and not the 10% reported by Wyeth. When he realized that patients in the study population first took the other drugs and were found resistant to them, this gave effexor an inherent advantage. Plus after giving a talk to a doctor, he found out that this doctor had seen a number of cases where his effexor patients developed high blood pressure and disputed his statistics. He realized that he was minimizing risks and exaggerating positive effects, all because he was being paid. His ethics and morals won out and he quit. He lost $30,000 in easy income, but felt better about himself in the process.
January 9, 2008 PSYCHIATRISTS TOP LIST IN DRUG MAKER GIFTS
As states begin to require that drug companies disclose their payments to doctors for lectures and other services, a pattern has emerged. Psychiatrists earn more money from drug makers that any other specialty. Vermont officials disclosed that drug company payments to psychiatrists more then doubled in 2006, an average $45,692, to 2005, $20,835.
January 9, 2008 SOY NUTS SEEM TO HELP WOMEN'S BLOOD PRESSURE
Substituting a half cup of soy nuts for other types of protein in a healthy diet may help lower a postmenopausal woman's blood pressure. For four weeks, 60 women average age 53 followed a low cholesterol diet that provided 30% energy from fat, 15% protein and 55 % carbohydrates. Then researchers divided them into two groups for an 8 week test. The first group followed the same diet without soy. The second group ate a half cup of soy nuts while reducing other protein. When hypertensive women were on the soy diet, they averaged a 9.9% reduction in systolic blood pressure (top number) and a 6.8 % reduction in diastolic pressure. Those with normal blood pressure also reduced their readings by 5.2 and 2.9%. This was published in The Archives of Internal Medicine. Hypertensive women also lowered their levels of LDL, the bad cholesterol.
January 9, 2008 ANTIBIOTICS NO MORE SUCCESSFUL THAN PLACEBO FOR SINUSES
In a recent study in the UK, 240 adults with acute sinsusitis were randomized to receive amoxicillin, nasal placebo, or oral placebo for one week. After two weeks, none of the active treatments were superior to placebo in symptom resolution by 10 days. These results are consistent with other previous studies showing that neither antibiotics or steroids are effective in acute sinusitis. This was published in Journal Watch.
January 8, 2008 SURGERY OR CONSERVATIVE TREATMENT FOR DISC HERNIATION?
In one study, 472 US patients with acute lumbar pain (LB) diagnosed with herniated discs were randomized to discectomy or conservative care. Both groups improved substantially two years later with no difference noted by the treatments.
January 8, 2008 BUT DOCTOR, WHAT WAS YOUR MARATHON TIME?
Interesting article in the NY Times on 1/3 regarding the physical condition of doctors. Do they walk the walk or just talk the talk or not talk at all? If you are an athlete, should you seek doctors who are athletes too? Can you take a fat overweight doctor seriously? How can he tell you to diet, exercise and stop smoking when he is the epitome of sickness? A doctor who is physically active is more likely to provide advice on exercise that will be meaningful to patients. On the other hand, athletic doctors may be so concerned with their patients remaining active that they may be less likely to take the easy way out and tell an active person who is injured or ill to stop exercising. This is in contrast to a doctor who is unfit, who tells his patient to find another sport, not taking into consideration the motivation and passion the patient has for that sport. Bottom line: talk to your doctor. Find out what his lifestyle is like. For the record, health is my number one priority. I am a 7 day per week runner (36th year) and I eat to live and not live to eat. My diet is very important to me. I encourage the same for my patients, but take into consideration their likes, dislikes and health problems.
January 8, 2008 STUDY FINDS VACCINE PRESERVATIVE NOT LINKED TO AUTISM
Los Angeles (AP) Autism cases in California continued to climb even after a mercury based vaccine preservative that some people blame for the neurological disorder was removed from routine childhood shots, a study has found.
Researchers from the State Public Health Department found that the autism rate in children rose continuously in the study period from 1995 to 2007. The preservative, thimerosal, has not been used in childhood vaccines since 2001, except for some flu shots.
Doctors said that the latest study added to the evidence against a link between thimerosal exposure and the risk of autism and that it should reassure parents that vaccinations do not cause autism. If there was a risk, the doctors said, autism rates should have dropped from 2004 to 2007.
Dr. Daniel Geschwind, a neurologist at the David Geffen School of Medicine at the University of California, Los Angeles, said the focus should be on exploring possible causes of autism, including genetic links.
“Something else must be at play,” said Dr. Geschwind, who had no connection with the study. “And we need to know what that is if we’re really serious about preventing autism.”
The results of the study are in the January issue of The Archives of General Psychiatry. The study did not explore why autism cases increased.
Officials say one
in 150 American
children have
autism, higher than
other estimates.
Researchers say it
is unclear whether
the increase stems
from changes in
classifying autism
or whether the
increase is actual.
25%
lifetime risk as determined by a predictive model).




